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Metabolically and clinically the most detrimental effects of IR are due to disruption in insulin-mediated control of glucose and lipid homeostasis in the primary insulin-responsive tissues: liver, skeletal muscle, and adipose tissue
Depletion of intracellular GSH appears to be critical for subsequent alterations in protein thiol and calcium homeostasis
The combination of these two medications does not magnify each other's side effects in clinically meaningful ways, though some patients may experience mild gastrointestinal symptoms during the initial titration phase
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The significant reduction of cholesterol from L-carnitine fed rabbits (table 3, group 6 vs
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