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If hemoglobin A1c (HbA1c) level is less than 1% from the individualized HbA1c target for a patient, metformin with or without sulfonylurea (depending on contraindication or intolerance) in combination with an -glucosidase inhibitor or a DPP4 inhibitor is recommended [4]

Clinical studies have documented indirect hormonal benefits primarily mediated through weight loss and improved insulin sensitivity

Outside clinical trials, no approved UK patient population exists for retatrutide

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Dose reduction of these concurrent medications may be necessary