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Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56

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In C57BL/6J mice, chronic exposure to the fungicide propamocarb induced significant changes in the gut microbial community structures, resulting in a significant increase in TMA levels in the feces (Wu et al., 2018)