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References: FDA Orange Book

**Heart rate (unique to retatrutide):** Glucagon activation causes a modest 5-10 bpm increase in resting heart rate

Table S2: Certainty of Evidence Table Author Contributions: All authors have read and agreed to the published version of the manuscript

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For other formulations, the general guideline is to take Janumet with meals to maximize absorption and reduce the likelihood of gastrointestinal side effects

Badshah I, Qazi NG, Ali F, Minhas AM, Alvi AM, Kandeel M, et al