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Furthermore, investigations involving patients undergoing dialysis have revealed an accelerated rate of telomere shortening, indicating that such changes may occur under conditions of physiological stress ( As individuals age, the buildup of senescent cells becomes progressively more apparent across different organs, including the kidneys, as evidenced by the expression of markers such as p21, p16 ink4a or senescence-associated -galactosidase (SA--Gal)

Additionally, environmental stressors can increase this base level of damage

GPX4 can serve as an essential bridge between the Hippo pathway and ferroptosis, and these two pathways have opposing regulatory effects on epithelial-to-mesenchymal transition (EMT)

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