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Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations

Phase 2 data showed approximately 24% mean weight reduction with Retatrutide at 12 mg versus approximately 21% with Tirzepatide at 15 mg in SURMOUNT-1 these are indirect, cross-trial figures

and inflammation both results from and contributes to dysbiosis and altered GLP-1 levels

For Ozempic, the starting dose is 0.25 mg, injected once a week

Nausea, vomiting, and other gastrointestinal symptoms are common, particularly when starting or increasing the dose and in T1D trials, these rates were similar to those seen in T2D and obesity trials