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Retrieved from Nauck, M.A

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3.2 Recruitment responses measured using NanoBiT complementation To attempt to understand why lixisenatide shows reduced cAMP signalling despite similar binding affinity to exendin-4, we also used a NanoBiT complementation approach (Dixon et al., 2016) to measure recruitment of mini-G proteins (Wan et al., 2018), and -arrestin-2, to GLP-1R