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Approximately 99% of the bioavailable tirzepatide is bound to plasma albumin

Side effects Commonly reported side effects include: Nausea Constipation Diarrhea Vomiting Decreased appetite Stomach (abdominal) pain Indigestion Other potential side effects: Fatigue Belching Heartburn Bloating Hair loss Gastroesophageal reflux disease Injection site reactions GI side effects are most common in the first few weeks and during dose increases

Disruptions in the supply of these critical inputs increase production lead times, delay product availability, elevate manufacturing costs, and constrain patient access to GLP-1 therapies across major global markets

BMJ 2011;343:d5928.ArticlePubMedPMC 24

Ethics declarations Conflict of interest The authors declare no conflict of interest

Most people do them in the abdomen, about two inches away from the belly button