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However, there have been rare cases of more serious side effects, such as pancreatitis and thyroid tumors

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Switching from orforglipron to an injectable GLP-1 is simpler pharmacokinetically, since orforglipron's effects clear within a day or two of the last dose

This distinction is part of why recomposition-focused research is generally structured around peptide pairings rather than single-compound protocols, since no one mechanism has been shown in the literature to independently account for both outcomes

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