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Indeed, recent evidence suggests that some of the cholesterol-independent effects of these agents may be mediated by inhibition of hepatic HMG-CoA reductase leading to subsequent reduction in circulating isoprenoid levels (28)

2.3 Cell culture and transfection of cells HEK-293 cells were cultured in Dulbeccos modified Eagles media, supplemented with 10% fetal calf serum, 100 U/mL penicillin, and 100 g/mL streptomycin

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