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People who might benefit the most from switching from semaglutide to tirzepatide include those who: Havent lost as much weight as they hoped to on semaglutide, or have run into a weight loss plateau Havent reached their target HbA1c levels on semaglutide, or are hoping for further reductions Have another health condition that only tirzepatide is FDA-approved to treat, such as obstructive sleep apnea If semaglutide hasnt been working well for you, it might be worth switching to tirzepatide