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Both Mounjaro and Zepbound injector pens and Zepbound single-dose vials don't contain preservatives and are approved for single-use only, so dose-splitting or microdosing is not contemplated by the FDA-label, the company notes

Dietary modifications should still be implemented, but this is the most forgiving dose level

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The STEP-HFpEF trial, in particular, found that semaglutide improved heart failure symptoms, walking distance, and overall quality of life in patients with HFpEF and obesity

Kaur K & Misra S, 2024