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Neither has an approved indication for fat loss

Semaglutide offers a new way to manage weight and diabetes

Food and Drug Administration (2025) Prior authorization: What is it, when might you need it, and how do you get it?, Harvard Health (2024) Save on Contrave, Contrave.com (2026) Find out if your medicine is covered, Aetna (2026) 2026 Aetna pharmacy drug guide (Standard plan), Aetna (2026) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Fang H, Tong W, Branham WS, Moland CL, Dial SL, Hong H, et al

Rather than mimicking gut hormones, Contrave works directly in the brain

Full therapeutic effects for weight management should be evaluated after 12 weeks at a maintenance dose (typically 10-15 mg weekly), while glycemic response for diabetes is assessed after 3-6 months on a stable dose