The fact that, like these women [10, 13, 81], the mouse model had smaller ovarian reserves, later pubertal onset and possibly lower ovulatory rates, and that this gene encodes a widely-expressed steroidogenic enzyme with key roles in the HPG axis, led us to hypothesize that the SRD5A1 downregulation might mediate the effect of the early-life events on these characteristics, and the mouse model enabled us to examine its role in the central control of reproduction in vitro and in vivo
Our analysis of the difference between groups in WM and GM (Fig
Bookshelf ID: NBK557767 DeBattista C (2024): Antipsychotic Agents & Lithium Chapter 29
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Vanderlelie and Perkins [7] evaluated the oxidative stress at the end of the reproduction in rats in placental and liver tissues, but they do not describe the alteration of GP activity, resulting from the coordination of tissue GSH reductase and GSSG peroxidase enzyme activities in both selenium deficiency and L-NAME oral administration
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