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Brierley, D

The GLP-1R/GIPR/GcgR triple-agonist retatrutide achieves body weight loss (~25%) in just two-thirds of the time, potentially surpassing the efficacy of Roux-en-Y gastric bypass [29]

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules

Liver function tests may be monitored in patients with pre-existing liver conditions

Answer: As of April 2026, 9 mg and 12 mg weekly are the doses with confirmed Phase 3 efficacy data, both from the TRIUMPH-4 readout (26.4 percent and 28.7 percent mean weight reduction at 68 weeks, respectively)

Medications that contain GLP-1s include Dulaglutide (Trulicity ), Exenatide (Byetta ), Semaglutide (Ozempic /Wegovy ) and Tirzepatide (Mounjaro /Zepbound )