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When the body becomes resistant to insulin, weight loss often plateaus
Several factors explain the lack of approval: insufficient clinical trials (no completed Phase 3 trials for most indications), safety concerns (FDA has identified specific adverse events), commercial considerations (patent status affects development investment), regulatory pathway (approval requires specific, rigorous documentation), and competition (Tesamorelin already approved for related indication)
Even when vision improves, some deficit often remains
As a result, a wide range of symptoms start appearing that often seem unrelated at first
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