Obesity is not just a risk factor for other diseases, such as cardiovascular diseases, type 2 diabetes (T2DM), arthritis, and some cancers (6), but also a complex disease with multiple causes, which has its own disabling ability, pathophysiology, and co-morbidities (7)
After the washout, begin the retatrutide dose schedule at 2mg, following the standard escalation
While many people regain weight, those who combine gradual dose reduction, structured nutrition, regular exercise, sleep optimization, and stress management maintain 5070% of their weight loss long-term
24.2% weight loss at 48 weeks This figure from the NEJM 2023 Phase 2 trial is the most-cited data point for Retatrutide
This level of efficacy is approaching that of bariatric surgery
130 For example, a popular dual agonist, tirzepatide (brand name Mounjaro), activates both GLP-1 and GIPR