Importantly, this regulation cascade can be exploited by targeting YBX1 to block AMPK protein synthesis and targeting GLUT1 to induce energy stress, which synergistically blunts tumor growth in vivo
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doi: 10.3389/fmed.2025.1638981 Received 31 May 2025 Accepted 14 August 2025 Published 10 September 2025 Volume 12 - 2025 Edited by Iain Brownlee, Northumbria University, United Kingdom Reviewed by Qianqian Zhang, Anhui University of Chinese Medicine, China Ion Hobai, Massachusetts General Hospital and Harvard Medical School, United States Updates Copyright 2025 Ukwade, Hernandez, Modi, Raza, Siegel, Nwachukwu, Sarraf, Memon, Booth, Cooper, Boulay and Mutlu
