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The shapes of the individual MACE component hazard ratio curves were similar to that of the 3-point composite MACE endpoint, which indicates consistent findings across the components

& Sellam, J

Collectively, these findings suggest that in individuals with T2DM, an FIB-4 score below 1.30 may be interpreted differently than in those without diabetes, underscoring the need to improve referral pathways when using the FIB-4 index as a first-line noninvasive test for people with T2DM

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Consequently, long-term CM may contribute to a healthier intestinal microbiota, potentially improving gut-brain communication through multiple mechanisms, including microbiota regulation (335)