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The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity

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Glycine is an amino acid that supports collagen synthesis, joint health, and sleep quality

Differences in vitamin-synthesizing ability of different microbial species might identify the potential mechanism for vitamin variation between healthy individuals and IBS patients

Int J Obes (Lond) 38 , 784793, (2014)