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Patients with peripheral atherosclerotic disease (multibed disease) should be treated as patients with very high or extreme cardiovascular risk, and the treatment goal should be reduction of LDL-C concentration by 50% from baseline and achievement of the target LDL-C concentration of 100 mg/dl (2.6 mmol/l) and/or elevated TG concentration (children 8 years of age (accumulating data support lowering of this age even to 6 years), and in children with homozygous FH 500 mg/dl (12.9 mmol/l)) [344]

Baseline laboratory investigations should be targeted based on individual risk factors and medical history rather than routine comprehensive panels

TMAO impairs mouse aortic vasodilation by inhibiting TRPV4 channels in endothelial cells

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10.1016/j.ejphar.2014.07.025 32 DegterevA.HitomiJ.GermscheidM.ChenI

This means Retatrutide users may be achieving meaningful cardiovascular protection simply as a secondary benefit of their weight management treatment