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Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e
a third of patients deteriorate to being house or bedbound (24, 2931), impacting activities of daily living, socialising, family life, emotional wellbeing, work, and education (23)
This integrated design addresses key limitations inherent to traditional high-throughput screening (HTS), namely, its low physiological relevance and inability to assess compound synergy in a controlled in vivo microenvironment, along with high compound consumption and reliance on static rather than real-time dynamic readouts
No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis
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