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Available Pre-Clinical and Clinical Evidence with SGLT2i and DPP4i agents Pre-Clinical Evidence A study on isolated human islet cells showed that linagliptin restored -cell function and turnover, which was impaired when islets were exposed to elevated glucose [21]

PMID: 27883260

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While BTRs (e.g., T2R5 and T2R38) have been reported to localize on L-cells in the small and/or large intestine, effects of BTR agonists on GLP-1 secretion are not well characterized in humans

La semaglutida y sus anlogos los famosos agonistas del receptor GLP-1 se han convertido en smbolos de una revolucin mdica que prometa transformar la lucha contra la obesidad