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In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (Hamilton and Holscher, 2009)

Medication levels build and taper over time Weekly GLP1 medications create a rhythm: levels rise after each injection, dip between shots, and build up over the first several weeks of treatment until they reach a steady state

Using GLP-1 agonists in high-risk individuals may delay or prevent the onset of obesity-related diseases

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However, current evidence does not strongly justify the cessation of GLP-1 RAs based on suicidality concerns

Many people may require ongoing treatment to maintain results