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Case reports of kidney and liver toxicity have been reported when used in high doses in young men

Holick, New England Journal of Medicine , 2007)

Cooper is vital for numerous biological processes including oxygenation, iron metabolism, and neurotransmission, while changes in copper oxidation are vital to dozens of enzymes including lysyl peroxidase, which controls connective tissue formation

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The material is provided as a lyophilized reference powder in sealed vials and is used for reproducible, standardized laboratory studies under controlled conditions

It was originally developed for anxiety and cognitive enhancement, but its immune-modulating properties make it relevant to autoimmune conditions with neuropsychiatric components