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However, endogenous GLP-1 is also produced by preproglucagon (PPG) neurons in the brain (Holt et al., 2019

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We estimated that with this sample size, the study would have 80% power to detect an absolute difference in the rate of improvement in ALT of 30 percentage points, with a two-sided type 1 error of 0.05

"Higher dose is always better." If the delivery system is poor, a 1000mg dose is less effective than a 200mg liposomal dose