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Review No Abstract [18] Lu, S.C

This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression

MTX-induced ER stress occurs predominantly through the PERK/CHOP-10 pathway (Koo et al., 2016) (Figure 1)

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Conjugated proteins were detected by an enhanced chemiluminescent immunoblotting detection system, the ChemiDoc Touch Imaging System (BIO RAD, CA, USA) was performed