Common side effects include nausea, vomiting, constipation, heartburn, and in rare cases cholecytitis and pancreatitis have been reported
The compound has been investigated in adipocyte-research and metabolic-disease research contexts where elevated NNMT activity has been linked to insulin resistance and adipose-tissue dysfunction
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
(Yumi Takasaki, 2002) A suitable alternative to cyanocobalamin /hydroxocobalamin in the treatment of vitamin B12 deficiency
Intended Use: Research and laboratory purposes only
Maximizing the Benefits of B12 Injections To ensure you get the most out of your B12 injections at The Derm Spa, we recommend the following: Stay Hydrated Proper hydration helps your body utilize B12 more effectively
