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Ripening and senescence of fruits may occur within weeks or months depending on the genotype that affects fruit metabolism through its interactions with endogenous and exogenous factors

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Folate deficiency and elevated homocysteine concentrations may increase cancer risk (see the article on Folate)

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Brands such as Obagi, Cosmelan and Dr Sylvia Advanced Clear Skin Program are among the known safe and effective lightening products that include prescription strength 4% hydroquinone to treat pigmentation and other spots in the skin