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Additionally, anxiety and stress trigger SNS hyperactivity, increasing renin release and angiotensin II, which promote renal vasoconstriction and tubulointerstitial damage (Wang and Dong, 2016) while elevated norepinephrine levels under mental distress accelerating kidney function decline (Tidgren and Hjemdahl, 1989)

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What would move this position is: a randomised, placebo-controlled trial in a defined population with an objective primary endpoint, a pre-registered protocol, and pharmacovigilance over a clinically meaningful duration

Pre-stained molecular weight standards were used (250 kDa25 kDa range), and unstained protein markers (200 kDa25 kDa range, Millipore) were detected after blotting using Ponceau red staining (data not shown)

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