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In extreme cases, studies on germ-free animals confirmed that the lack of intestinal microbiota would lead to the degradation of intestinal mucosal barrier function, the specific manifestations are the reduction of the overall intestinal surface area, shorter intestinal villi, the reduction of intestinal crypt, the increase in intestinal permeability as well as the thinning and instability of mucous layer [81, 82]

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Single nucleotide variations (polymorphisms) in the sequence of genes can modify gene expression level and the stability and activity of the synthesized proteins

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Yellowing of the skin or the whites of the eyes (jaundice)

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Disease-specific as well as generic quality of life is widely impacted in autoimmune hypothyroidism and improves during the first six months of levothyroxine therapy

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