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Moreover, leptin appeared to preferentially impact the density of GLP-1 inputs onto CRH neurons, as we observed a greater number of GCG-Cre::SynTom-labeled terminals in close association with labeled CRH neurons in adult GCG-Cre::SynTom::Lep ob/ob mice than in GCG-Cre::SynTom::WT controls (Figure 4DF

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This was confirmed in the recent AngioSafe study which showed no effect of GLP-1RA therapy on angiogenesis and no association between GLP-1 exposure and severe DRP was shown (129)

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[DOI] [PMC free article] [PubMed] [Google Scholar] KK ELJ, Kobe HJ (2021) I8F-JE-GPGO Statistical Analysis Plan Addendum Version 2 1

The young company has four GLP-1-related programs we also described previously