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495 Initial studies of the role of GDI1 were focused on neurones

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SalB has demonstrated its effectiveness in reducing diethyl nitrosamine-induced HF via altering the TGF-/Smad and mitogen-activated protein kinase (MAPK) signaling pathways (Wu et al., 2019)

Assays of endothelial cell migration showed that BPC-157 enhanced the chemotactic response of endothelial cells

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While STEP-HFpEF was underpowered to truly detect outcome differences, the difference observed supports the need for larger, outcomes-driven trials in obese patients with HFpEF