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All four of these inhibitors reduce the reabsorption of filtered glucose, decrease the renal threshold for glucose, and promote urinary glucose excretion. Studies show that SGLT-2 use in diabetic kidney transplant recipients resulted in a decrease in hemoglobin A1C. There were potential side effects including increased infection risk and fluctuating allograft function

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In general, it is much safer to take the name-brand versus compounded versions. 3