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SSG control Under homeostatic conditions, CASP8 acts as the primary molecular "brake" on necroptosis by cleaving and inactivating RIPK1 and RIPK3

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However, it can also be detrimental referring ME/CFS patients to psychiatrists (39), not because it excludes other diagnoses, but rather if patients are labelled as hypochondriacs and their condition is attributed solely to psychosomatic origins (23)