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Dizziness or lightheadedness : Orthostatic symptoms combined with urinary changes may indicate volume depletion requiring fluid management adjustment
On the one hand, the activation of endoplasmic reticulum stress pathway in cancer cells can inhibit ferroptosis and participate in the induction of drug resistance
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Evidence favouring this hypothesis includes: (1) overproduction in INS-1E cells or in rat pancreatic islets of glutamate decarboxylase, an enzyme that decarboxylates glutamate in the cytoplasm, led to a reduced cellular glutamate content that correlated with the impaired GSIS [68]
10.3390/biom9030100 17
doi: 10.1126/scitranslmed.3010626 82 GrandiGMuellerMDPapadiaAKocbekVBersingerNAPetragliaFet al
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