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GLP-1 RAs are increasingly viewed not only as antidiabetic medications, but as a frontline treatment option for obesitya chronic and often intractable condition

Meaningful body weight loss (510% of starting weight) typically emerges within 68 weeks as dosing reaches therapeutic levels

Tolerance loss and tachyphylaxis True tachyphylaxis, where a previously effective dose loses efficacy despite unchanged circumstances, is uncommon but possible with tirzepatide

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Shan et al., 2014)

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