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Combining GLP-1 agonists (such as liraglutide, semaglutide and tirzepatide) with metformin can offer several benefits for weight loss, especially in individuals with type 2 diabetes or obesity: Synergistic Effects : GLP-1 agonists and metformin work through different mechanisms to lower blood sugar levels and promote weight loss

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AstraZenecas GLP-1 pill, elecoglipron, which in phase II trials showed clinically meaningful weight loss of up to 10.5% at 26 weeks and 11.8% at 36 weeks in the highest-dose groups of adults without diabetes 21

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doi:10.1002/fsn3.2145

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