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The physical sensations associated with gastric distress may mimic or precipitate panic-like symptoms, particularly in patients with pre-existing anxiety disorders

therefore, research into longer acting GCGR/GLP-1R dual agonists is warranted

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Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes

Common side effects with dose escalation include nausea, vomiting, constipation, and reduced appetite, typically occurring most intensely for 1-2 weeks after each dose increase before tolerating improves