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Exendin-4 is a 39 amino acid peptide with 53% identity to GLP-1 (34) and is fully active at GLP-1 receptors and not degraded by DPP-4

Semaglutide (Ozempic for diabetes, Wegovy for weight loss) represents the most effective pure GLP-1 agonist currently available

Topical antihistamine creams are not recommended for this purpose, as they carry a risk of contact sensitisation and are not supported by UK clinical guidance (BNF

Personalized Dosing Medication dosage and timing are customized to minimize discomfort and support long-term success

The launch comes amid intensifying competition with Novo Nordisk in the fast-growing obesity drug market

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