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We and others have shown that a striking pathological feature of regenerated skeletal muscle in the dystrophinopathies is the presence of abnormally branched fibers which dramatically increase in both number and complexity with age ( in vitro experiments has shown that NAC can prevent eccentric contraction force loss in fast twitch mdx muscles (Whitehead et al., 2008

Gut 2008, 57 (7), 957965

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The coordinated activation of HSPs, ROS detoxification systems, and transcriptional regulators underscores the multi-layered nature of thermotolerance