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How often shots are needed depends on how bad the deficiency is and how well the patient responds to treatment

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For instance, a 2019 paper in JAMA Network Open reported that patients treated in a functional medicine setting showed greater improvements in patient-reported quality of life compared to those receiving conventional care

doi: 10.1016/j.abb.2025.110465 176 McDonnellMAWangDKhanSMVander HeidenMGKelekarA