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Gramer, Gwendolyn et al

Phase 2 data showed improved liver enzyme levels, reduced steatosis, and decreased liver stiffness

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The NTS itself contains GLP-1 producing neurons which signal to decrease food-based reward in the mesolimbic VTA and NAc, which in turn impact memory and emotional processing in the hippocampus and amygdala [40]

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Specifically, the study reveals a significant reduction in serum melatonin levels in the model group compared to the control, suggesting the induction of stress