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Colonic biopsies from these patients also show reduced GLP-1R expression, suggesting that decreased GLP-1 and GLP-1R expression may underlie the efficacy of ROSE-010 in alleviating IBS-C abdominal pain [61]

Brighten: I think it would be really wise for us to say what we're talking about is disordered eating

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First, GLP-1 receptors are found not only in the pancreas and gastrointestinal tract but also in various other tissues throughout the body, raising theoretical questions about how chronic stimulation of these receptors might affect cell growth

Seo et al., 2017)

Healthcare professionals who encounter patients using unlicensed peptides should approach the conversation without judgement, document use carefully, and consider appropriate baseline investigations including liver function tests, lipid profile, and renal function