Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)
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These variants may facilitate the presentation of self-antigens (e.g., insulin peptides) to T cells and initiate an autoimmune cascade against pancreatic beta cells [2, 3]
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Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial
