Retatrutide mimics three (GLP-1, GIP, and glucagon)
Starting at a smaller dose allows the body to acclimate to the medication before the dosage is stepped up over time
One strategy involves extending the initial 1mg phase to six or eight weeks instead of four
This may be a convenient option for those who cannot easily access in-person appointments due to long wait lists, location, finances, or health
With GLP-1 drugs widely available via direct-to-consumer websites and, increasingly, directly from drug manufacturers, most adults who have taken these medications say they got them from their primary health care provider or a specialist (76%), while about one in six (17%) report getting them from an online provider or website
New 2025 research explains why both happen: this drug activates CB1 and CB2 receptors