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Rare side effects of B12 shots (require medical attention) Serious reactions to B-12 shots are uncommon, but its important to be aware of them: Allergic reaction, including rash, hives, dizziness, or trouble breathing Significant swelling, pain, or warmth that worsens at the injection site Palpitations or chest discomfort Signs of drug interactions, especially if you take multiple prescription medications If you experience symptoms that feel intense, progressive, or unusual, you should contact your provider right away

Miller Professor in the Department of Basic & Translational Sciences in the University of Pennsylvania School of Dental Medicine

Tendon and ligament repair: Animal studies demonstrate accelerated healing of tendons and ligaments, which explains its popularity for joint and connective tissue injuries

Both peptides stimulate growth hormone release, but they differ in mechanism, selectivity, and side effect profile

Benefits accrue gradually over 36 months

Nat Rev Immunol 17(3):151164