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To this end, we collected all predicted tier-1 targets across all cells from the individual datasets and identified 254 enzymes that occurred as shared tier-1 targets in at least one cell across all datasets (Supplementary Data 6 and Supplementary Data 1)

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For example, the disulfide 23 (HA08) that comprises a 13-membered ring system, a -turn mimetic in the C-terminal and a -amino acid residue in the N-terminal ring system exhibits a Ki of 3.3 nM

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