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In addition to dietary and pharmaceutical influences, new research confirms that GLP-1 secretion is impacted by sex as well as many personal health factors, including glucose tolerance and overall metabolic health, body weight, microbiome composition, and even eating behaviour itself (Huber et al., 2024)

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Additionally, Li et al (117) demonstrated that GLP-1R activation inhibited the TGF-1/Smad3 and ERK1/2 signaling pathways, preventing epithelial-to-mesenchymal transition, thus reducing extracellular matrix secretion and deposition, and alleviating renal fibrosis