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Conversely, other evidenceincluding meta-analyses and animal modelssupports increased central gain in tinnitus (Chen et al., 2021

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F., Busby-Whitehead, J., et al

Around 40% of the participants were also using an SLG2 inhibitor before the trial began

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This could be due to ALCs quick absorption and capacity to cross the blood-brain barrier, potentially altering the gut microbiota composition and limiting the abundance of TMA-producing bacteria